We strive to bring innovative solutions to improve glycoprotein therapeutics by custom-designed glycans
Glycosylation is the most abundant and diverse of the post-translational modifications of proteins that involves around 200 glycosyltransferase enzymes. In our body glycosylation is needed for correct folding, stability, transport and function of proteins and serve important roles in health and diseases. It is also a key component of glycoprotein therapeutics, as glycans can affect its products' stability, PK/PD, antigenicity and activity.
GlycoDisplay is a spin-out from Copenhagen Center for Glycomics, University of Copenhagen, with its expertise lies in rational and combinatorial gene engineering of the genes encoding glycosyltransferases, enabling generation of custom-designed glycans. We have developed proprietary design matrices for genetic engineering of different types of protein glycosylation including N-linked, O-linked, and glycosaminoglycans in mammalian cells.
The GlycoDisplay platform consists of a panel of glycoengineered cell lines each produce different glycoforms, allowing display of the glycoforms in a natural context, which serves as:
- Sustainable resource to produce glycoproteins for therapeutic use
- Cell based array for interrogation of glycan-binding proteins, such as antibodies, lectins, and microbes