Avian influenza viruses primarily use α2-3-linked sialic acids as their preferred receptors, whereas human influenza viruses typically prefer α2-6-linked sialic acids.
GlycoDisplay's glycoengineered HEK293 cells, which express either α2-3-linked or α2-6-linked sialic acids, were used to study how mutations in influenza hemagglutinin influence its binding preference for α2-6-linked versus α2-3-linked receptors.
New article "Direct observation of glycans bonded to proteins and lipids at the single-molecule level" is published.
Mucin reporters produced by GlycoDisplay platform was used for the first direct single-molecule imaging using low-temperatuer scanning tunneling microscopy.
Below you can see the image of single MUC1 molecule mucin reporter (200 aminoacid with 25 trisaccharides):
